PXD024259 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SOX6 interacting proteins' identification in K562 cells for the regulation of γ-globin gene expression research |
Description | Human fetal γ-globin gene is developmentally silenced around the birth, and reactivation of γ-globin gene in adulthood sheds new light on ameliorating symptoms of hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemias. However, the precise regulation process of γ-globin remains incompletely understood. Here, we found that a new protein directly interacted with SOX6 and exerted a significant repression effect on the expression of γ-globin gene in erythroid cells. Further studies have demonstrated that it bound directly to γ-globin gene promoter via octamer binding motif, which in turn suppressed the transcriptional activity of γ-globin gene promoter. Thus, these data indicate that this new protein acts as a novel transcriptional repressor in the regulation of γ-globin gene expression through direct promoter binding, implying a potential alternative therapeutic target for the treatment of SCD and β-thalassemias. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-16 |
AnnouncementXML | Submission_2022-02-16_15:49:56.231.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | li xinyu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-19 07:38:01 | ID requested | |
⏵ 1 | 2022-02-16 15:49:57 | announced | |
Publication List
Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, Cui S, Xu P, Nakamura Y, Kurita R, Chen B, Huang DCS, Liu DP, Liu M, Zhao Q, Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res, 49(17):9711-9723(2021) [pubmed] |
Keyword List
submitter keyword: K562, SOX6, Globin, gene expression |
Contact List
Quan Zhao |
contact affiliation | State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. |
contact email | lixinyunju@gmail.com |
lab head | |
li xinyu |
contact affiliation | Nanjing University |
contact email | lixinyunju@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024259
- Label: PRIDE project
- Name: SOX6 interacting proteins' identification in K562 cells for the regulation of γ-globin gene expression research