PXD024254

PXD024254 is an original dataset announced via ProteomeXchange.

Title	Identification of full length wild-type and mutant huntingtin interacting proteins by crosslinking immunoprecipitation in mice brain cortex
Description	Huntington’s Disease is a neurodegenerative disorder caused by a CAG expansion in exon1 of the huntingtin (Htt) gene. The resulting polyglutamine expansion in the ubiquitously expressed mutant Htt (mHtt) protein leads to selective neurodegeneration. In this study we set out to identify interacting proteins of full length wild-type and mHtt protein in the mice cortex brain region in order to get a better understanding of the processes involved in HD pathology.
HostingRepository	PRIDE
AnnounceDate	2021-08-25
AnnouncementXML	Submission_2021-08-25_04:53:28.297.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024254
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Arzu Tugce Guler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-18 22:00:27	ID requested
1	2021-06-21 03:41:50	announced
⏵ 2	2021-08-25 04:53:29	announced	2021-08-25: Updated project metadata.

Sap KA, Guler AT, Bury A, Dekkers D, Demmers JAA, Reits EA, Identification of Full-Length Wild-Type and Mutant Huntingtin Interacting Proteins by Crosslinking Immunoprecipitation in Mice Brain Cortex. J Huntingtons Dis, 10(3):335-347(2021) [pubmed]

submitter keyword: Mouse, Brain, Huntington's Disease, FLAG immunoprecipitation

Eric Reits
contact affiliation	Professor Cellular Imaging, PI Huntington degradation research groupleader, Department of Medical Biology, Amsterdam UMC location AMC, Amsterdam, The Netherlands
contact email	e.a.reits@amsterdamumc.nl
lab head
Arzu Tugce Guler
contact affiliation	Academisch Medisch Centrum
contact email	a.t.guler@amc.uva.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD024254

PRIDE project URI

• PRIDE
  1. PXD024254
     1. Label: PRIDE project
     2. Name: Identification of full length wild-type and mutant huntingtin interacting proteins by crosslinking immunoprecipitation in mice brain cortex