PXD024229

PXD024229 is an original dataset announced via ProteomeXchange.

Title	Associations between cellular energy and pediatric inflammatory bowel disease patient response to treatment
Description	Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascending colon biopsies from 119 pediatric patients to characterize disease pathogenesis and the impacts of treatment. Consistent with previous findings, we report an altered proteome in IBD patients that indicates impaired mitochondrial function. Gene ontology revealed that proteins downregulated in inflammation are associated with metabolism, whereas upregulated proteins contribute to protein processing. A comparison of proteomes from CD patients before and after therapeutic intervention identified over 100 proteins that are significantly different between patients that responded and those that did not respond to therapy; creatine kinase B was elevated before treatment in patients with mucosal healing after treatment, whereas basigin increased after treatment in responsive patients.
HostingRepository	PRIDE
AnnounceDate	2021-08-26
AnnouncementXML	Submission_2021-08-26_05:05:04.722.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhibin Ning
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-18 01:39:05	ID requested
⏵ 1	2021-08-26 05:05:05	announced

Starr AE, Deeke SA, Ning Z, de Nanassy J, Singleton R, Benchimol EI, Mack DR, Stintzi A, Figeys D, Associations between Cellular Energy and Pediatric Inflammatory Bowel Disease Patient Response to Treatment. J Proteome Res, 20(9):4393-4404(2021) [pubmed]

submitter keyword: Inflammatory Bowel Disease, Proteomics, Pediatric

Daniel Figeys
contact affiliation	Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.
contact email	dfigeys@uottawa.ca
lab head
Zhibin Ning
contact affiliation	research associate
contact email	ningzhibin@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024229
     1. Label: PRIDE project
     2. Name: Associations between cellular energy and pediatric inflammatory bowel disease patient response to treatment