PXD024212 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Alterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides |
Description | Flucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:19:02.384.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Swamy Kumar Polumuri |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | cysteinylation (disulfide with free L-cysteine); acetylated residue; monohydroxylated residue; L-citrulline |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-17 02:58:27 | ID requested | |
1 | 2021-02-17 11:31:32 | announced | |
⏵ 2 | 2024-10-22 05:19:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Human Immuno-Peptidome Project (HUPO-HIPP) (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: Flucloxacillin, HLA-B*57:01, drug hypersensitivity, transgenic mice, hapten, immunogenicity |
Contact List
Michael A. Norcross, MD Montserrat Puig, PhD |
contact affiliation | Laboratory of Immunology, Division of Biotechnology Review and Research III, Office of Biotechnology Products,Center for Drugs Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA |
contact email | Montserrat.Puig@fda.hhs.gov |
lab head | |
Swamy Kumar Polumuri |
contact affiliation | FDA |
contact email | swamykumar.polumuri@fda.hhs.gov |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD024212 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024212
- Label: PRIDE project
- Name: Alterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides