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PXD024212

PXD024212 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAlterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides
DescriptionFlucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:19:02.384.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSwamy Kumar Polumuri
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListcysteinylation (disulfide with free L-cysteine); acetylated residue; monohydroxylated residue; L-citrulline
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-17 02:58:27ID requested
12021-02-17 11:31:32announced
22024-10-22 05:19:02announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Human Immuno-Peptidome Project (HUPO-HIPP) (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: Flucloxacillin, HLA-B*57:01, drug hypersensitivity, transgenic mice, hapten, immunogenicity
Contact List
Michael A. Norcross, MD Montserrat Puig, PhD
contact affiliationLaboratory of Immunology, Division of Biotechnology Review and Research III, Office of Biotechnology Products,Center for Drugs Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
contact emailMontserrat.Puig@fda.hhs.gov
lab head
Swamy Kumar Polumuri
contact affiliationFDA
contact emailswamykumar.polumuri@fda.hhs.gov
dataset submitter
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Dataset FTP location
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PRIDE project URI
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