PXD024212

PXD024212 is an original dataset announced via ProteomeXchange.

Title	Alterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides
Description	Flucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:19:02.384.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Swamy Kumar Polumuri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	cysteinylation (disulfide with free L-cysteine); acetylated residue; monohydroxylated residue; L-citrulline
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-17 02:58:27	ID requested
1	2021-02-17 11:31:32	announced
⏵ 2	2024-10-22 05:19:02	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: Human Immuno-Peptidome Project (HUPO-HIPP) (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Flucloxacillin, HLA-B*57:01, drug hypersensitivity, transgenic mice, hapten, immunogenicity

Michael A. Norcross, MD Montserrat Puig, PhD
contact affiliation	Laboratory of Immunology, Division of Biotechnology Review and Research III, Office of Biotechnology Products,Center for Drugs Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
contact email	Montserrat.Puig@fda.hhs.gov
lab head
Swamy Kumar Polumuri
contact affiliation	FDA
contact email	swamykumar.polumuri@fda.hhs.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD024212

PRIDE project URI

• PRIDE
  1. PXD024212
     1. Label: PRIDE project
     2. Name: Alterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides