PXD024194

PXD024194 is an original dataset announced via ProteomeXchange.

Title	Identification of TI-4-interacting proteins
Description	Transcriptional co-activator with PDZ-binding motif (TAZ) (the official gene name; WWTR1) interacts with transcription factors in the nucleus but when phosphorylated, translocates to the cytoplasm and undergoes degradation. Chemical compounds that modulate the subcellular localization of TAZ are supposed to activate or inhibit TAZ. We identified a compound that shifts TAZ to the cytoplasm independently of phosphorylation and named it TI-4. We used affinity beads and obtained as a putative target of TI-4 Chromosomal Segregation 1 Like (CSE1L), which is involved in the recycling of importin alpha and is known as a biomarker of cancer malignancy.
HostingRepository	PRIDE
AnnounceDate	2021-09-10
AnnouncementXML	Submission_2021-09-10_00:33:33.525.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024194
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Junichi MARUYAMA
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-16 00:05:05	ID requested
⏵ 1	2021-09-10 00:33:34	announced

Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y, cells. J Biol Chem, 297(1):100803(2021) [pubmed]

submitter keyword: Homo sapiens, TAZ, TI-4

Yutaka HATA
contact affiliation	Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
contact email	yuhammch@tmd.ac.jp
lab head
Junichi MARUYAMA
contact affiliation	Department of Medical Biochemistry, Tokyo Medical and Dental University
contact email	jmaruyama.mbc@tmd.ac.jp
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024194
     1. Label: PRIDE project
     2. Name: Identification of TI-4-interacting proteins