PXD024188

PXD024188 is an original dataset announced via ProteomeXchange.

Title	Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders
Description	In this study, we compared the effects of two cytokine treatments on the proteome of human Th-1 cells. We used saturating doses of murine single-chain IL-27 (EBI3+p28, 10nM) and HyperIL-6 (20nM) and continuously stimulated cells of three donors with the two cytokines for 24h or left untreated.
HostingRepository	PRIDE
AnnounceDate	2021-05-05
AnnouncementXML	Submission_2021-05-04_22:30:25.958.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephan Wilmes
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-15 09:16:52	ID requested
⏵ 1	2021-05-04 22:30:26	announced

Wilmes S, Jeffrey PA, Martinez-Fabregas J, Hafer M, Fyfe PK, Pohler E, Gaggero S, L, ó, pez-Garc, í, a M, Lythe G, Taylor C, Guerrier T, Launay D, Mitra S, Piehler J, Molina-Par, í, s C, Moraga I, Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses. Elife, 10():(2021) [pubmed]

submitter keyword: human Th-1, IL-27, IL-6

Ignacio Moraga-Gonzalez
contact affiliation	Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
contact email	i.moragagonzalez@dundee.ac.uk
lab head
Stephan Wilmes
contact affiliation	University of Dundee, School of Life Sciences, Division of Cell Signalling and Immunology
contact email	swilmes@dundee.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD024188

PRIDE project URI

• PRIDE
  1. PXD024188
     1. Label: PRIDE project
     2. Name: Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders