PXD024150

PXD024150 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of triple negative mouse breast cancer isografts after electro-hyperthermia treatment
Description	Modulated electro-hyperthermia (mEHT) is a selective cancer treatment used in human oncology complementing other therapies. During mEHT, a focused electromagnetic field (EMF) is generated within the tumor, by elevated oxidative glycolysis (Warburg effect) and conductivity of the tumor. The EMF induce cell death by thermal and non-thermal effects. Here we investigated an aggressive, therapy resistant triple negative breast cancer (TNBC) model. 4T1/4T07 isografts inoculated orthotopically into female BALB/c mice were treated with mEHT 3-5 times. mEHT induced the upregulation of the stress related Hsp70 and cleaved caspase-3 proteins, resulting in effective inhibition of tumor growth and proliferation.
HostingRepository	PRIDE
AnnounceDate	2021-04-14
AnnouncementXML	Submission_2021-04-13_22:54:37.329.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024150
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Marko Fonovic
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-11 22:57:00	ID requested
⏵ 1	2021-04-13 22:54:37	announced

Dataset with its publication pending

submitter keyword: Orbitrap, proteomics, breast cancer, stress response

prof. dr. Marko Fonović
contact affiliation	Department of Biochemistry and Molecular and Structural Biology, Jozef Stefen Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia
contact email	marko.fonovic@ijs.si
lab head
Marko Fonovic
contact affiliation	Jozef Stefan Institute
contact email	marko.fonovic@ijs.si
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024150
     1. Label: PRIDE project
     2. Name: Proteomic analysis of triple negative mouse breast cancer isografts after electro-hyperthermia treatment