PXD024122

PXD024122 is an original dataset announced via ProteomeXchange.

Title	The ribosome-associated N-terminal acetyltransferase A regulates proteome stability in plants
Description	N-terminal acetylation is one of the most common protein modifications in eukaryotes. The NatA complex is the dominant regulator of the N-acetylome in all eukaryotes. Here, we show that the imprinting of the proteome with acetylation marks by the essential NatA complex is a critical trigger for stabilizing plant proteins. Depleting 70% of the NatA activity by downregulation of the catalytic or the ribosome anchoring subunit causes 4-fold faster degradation of total proteins in Arabidopsis. This proteome dataset compares the NatA depleted Arabidopsis lines amiNAA10 and amiNAA15 to wild type Arabidopsis.
HostingRepository	PRIDE
AnnounceDate	2022-04-13
AnnouncementXML	Submission_2022-04-13_03:33:22.073.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-10 23:54:08	ID requested
⏵ 1	2022-04-13 03:33:22	announced

Dataset with its publication pending

submitter keyword: N-terminal Acetylation

Matthias Mann
contact affiliation	Director, Max-Planck-Institute for Biochemistry, Am Klopferspitz 18, Martinsried, Germany
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024122
     1. Label: PRIDE project
     2. Name: The ribosome-associated N-terminal acetyltransferase A regulates proteome stability in plants