PXD024053

PXD024053 is an original dataset announced via ProteomeXchange.

Title	BoLA-DRimmunopeptidomics in Theileria parva infected, bovine cell lines
Description	The ability to maintain T.parva-infected cell lines as rapidly proliferating cells in vitro that express high levels of both MHCI and MHCII, makes this a particularly amenable system in which to apply MHCp elution analysis. Furthermore, the ability of T. parva-infected cells to recall antigen-specific T-cells without the need for supplementary APCs indicates that the peptides presented by T. parva are those that stimulate T-cell responses. We have utilised the repertoire of bovine derived peptides from MHCp elution studies conducted on T. parva-infected cells to define the peptide binding motifs of a variety of BoLA-MHCI and BoLA-DR molecules and facilitated the development of novel more accurate peptide binding prediction algorithms.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_15:52:50.915.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024053
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicola Ternette
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-08 07:12:39	ID requested
⏵ 1	2022-05-19 15:52:51	announced

Fisch A, Reynisson B, Benedictus L, Nicastri A, Vasoya D, Morrison I, Buus S, Ferreira BR, Kinney Ferreira de Miranda Santos I, Ternette N, Connelley T, Nielsen M, Integral Use of Immunopeptidomics and Immunoinformatics for the Characterization of Antigen Presentation and Rational Identification of BoLA-DR-Presented Peptides and Epitopes. J Immunol, 206(10):2489-2497(2021) [pubmed]

submitter keyword: Bovine leukocyte antigen

Theileria parva

MHC, immunppeptidomics

Nicola Ternette
contact affiliation	University of Oxford
contact email	nicola.ternette@ndm.ox.ac.uk
lab head
Nicola Ternette
contact affiliation	University of Oxford
contact email	nicola.ternette@ndm.ox.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD024053

PRIDE project URI

• PRIDE
  1. PXD024053
     1. Label: PRIDE project
     2. Name: BoLA-DRimmunopeptidomics in Theileria parva infected, bovine cell lines