PXD024012

PXD024012 is an original dataset announced via ProteomeXchange.

Title	Systemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Description	Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients with different forms of HFpEF to identify unique molecular mechanisms and pathways. We performed unbiased, comprehensive proteomic analyses of 31 gender- and BMI-matched plasma samples from patients with acute HFpEF (n=8), chronic HFpEF (n=9) and hypertrophic cardiomyopathy (HCM; n=14). We identified leucine-rich alpha-2-glycoprotein 1 (LRG1) as an aberrant protein across all three forms of HFpEF. We reported perturbations in signalling pathways in HFpEF mainly driven by complement/coagulation/protease and extracellular matrix (ECM) proteins, highlighting the haemostatic disturbances, notably platelet degranulation caused by systematically elevated platelet cytosolic Ca2+. We provided a publicly available online application (https://hao-chen-uts-99171821.shinyapps.io/HFpEF-Proteomics/) of our findings.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:17:28.439.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024012
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew Padula
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-05 03:07:41	ID requested
1	2023-03-10 19:33:06	announced
⏵ 2	2023-11-14 08:17:29	announced	2023-11-14: Updated project metadata.

10.6019/PXD024012;

Chen H, Tesic M, Nikolic VN, Pavlovic M, Vucic RM, Spasic A, Jovanovic H, Jovanovic I, Town SEL, Padula MP, McClements L, Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction. Biomolecules, 12(10):(2022) [pubmed]

submitter keyword: biomarkers, heart failure with preserved ejection fraction, plasma, hypertrophic cardiomyopathy, LC-MS/MS

Lana McClements
contact affiliation	School of Life Sciences, Faculty of Science, University of Technology Sydney.
contact email	lana.mcclements@uts.edu.au
lab head
Matthew Padula
contact affiliation	University of technology Sydney
contact email	matthew.padula@uts.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD024012

PRIDE project URI

• PRIDE
  1. PXD024012
     1. Label: PRIDE project
     2. Name: Systemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.