PXD023954

PXD023954 is an original dataset announced via ProteomeXchange.

Title	Chicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides
Description	Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer decisive resistance or susceptibility to many viruses. Examples are Marek's disease virus (MDV) and Infectious bursal disease virus (IBDV). We used a new in vitro infection system and immunopeptidomics to identify peptides presented to T lymphocytes via classical MHC class II molecules.
HostingRepository	PRIDE
AnnounceDate	2021-09-10
AnnouncementXML	Submission_2021-09-10_00:25:56.911.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Ghosh
SpeciesList	scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-03 01:55:32	ID requested
⏵ 1	2021-09-10 00:25:57	announced

Halabi S, Ghosh M, Stevanovi, ć S, Rammensee HG, Bertzbach LD, Kaufer BB, Moncrieffe MC, Kaspers B, H, ä, rtle S, Kaufman J, The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif. PLoS Biol, 19(4):e3001057(2021) [pubmed]

submitter keyword: Chicken MHC, MHC class I, MHC class II, MDV, IBDV, immunopeptidomics

Stefan Stevanovic
contact affiliation	Department of Immunology, Interfaculty Institute for Cell Biology, Tübingen, Germany
contact email	stefan.stevanovic@uni-tuebingen.de
lab head
Michael Ghosh
contact affiliation	Department of Immunology, Tübingen
contact email	Michaelghosh@gmx.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023954
     1. Label: PRIDE project
     2. Name: Chicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides