PXD023937

PXD023937 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of secretory granules in dopaminergic neurons of Parkinson`s disease
Description	Parkinson disease (PD) is the second most common age-related neurodegenerative disorder, which is related to neurotransmitter secretion impartment and the dysfunction of vesicle transport. Secretory granules (SGs) are a class of intracellular vesicles different from synaptic vesicles (SVs) in neurons and the neuroendocrine cells. They represent the primary subcellular site for the biosynthesis, storage and releasing of the neuropeptides, neurotransmitters and hormones. In the current study, we characterized the proteome of secretory granules in dopaminergic neurons in PD. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was used to identify proteins in SGs. A total of 4249 proteins were identified in the SGs in normal and MPP+-treated SH-Sy5Y dopaminergic neurons in total. This study regarded the biological alternations of SGs in PD as an entry point. By studying the significantly differentially expressed proteins, it is helpful to better understand the molecular mechanisms of SGs disorders in the pathology of PD, and provide a basis for vesicle transport theory in pathogenesis of PD.
HostingRepository	PRIDE
AnnounceDate	2021-08-26
AnnouncementXML	Submission_2021-08-26_03:46:50.702.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaoni ZHan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-02 01:43:00	ID requested
⏵ 1	2021-08-26 03:46:51	announced

Wen G, Pang H, Wu X, Jiang E, Zhang X, Zhan X, Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease. Aging (Albany NY), 13(16):20335-20358(2021) [pubmed]

submitter keyword: Parkinson`s disease, secretory granule, vesicle transport

Xiaoni Zhan
contact affiliation	Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Beijing, China
contact email	xnzhan@cmu.edu.cn
lab head
Xiaoni ZHan
contact affiliation	China Medical University
contact email	xnzhan@cmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD023937

PRIDE project URI

• PRIDE
  1. PXD023937
     1. Label: PRIDE project
     2. Name: Proteomic analysis of secretory granules in dopaminergic neurons of Parkinson`s disease