PXD023899

PXD023899 is an original dataset announced via ProteomeXchange.

Title	Proteome profiling of normal epithelium, tubular adenoma, tubulovillous adenoma, high-grade neoplasia, cancer tissues in colorectum
Description	Most of the carcinogenesis of colorectal cancer (CRC) follows the normal-adenoma-carcinoma (N-A-C) sequence. We aimed to identify the key proteins in the N-A-C sequence and describe the proteomic pattern of tubular adenoma, tubulovillous adenoma and high-grade neoplasia. This study used high-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with quantitative 5-plex tandem mass tag labeling, to profile protein changes in normal epithelium, tubular adenoma, tubulovillous adenoma, high-grade neoplasia, cancer tissues in colorectum.
HostingRepository	iProX
AnnounceDate	2021-01-30
AnnouncementXML	Submission_2023-02-20_22:56:02.735.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Ge
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-31 21:09:23	ID requested
1	2021-01-31 21:11:44	announced
⏵ 2	2023-02-20 22:56:05	announced	2023-02-21: Update information.

Zhang Y, Li CY, Pan M, Li JY, Ge W, Xu L, Xiao Y, Exploration of the Key Proteins of High-Grade Intraepithelial Neoplasia to Adenocarcinoma Sequence Using In-Depth Quantitative Proteomics Analysis. J Oncol, 2021():5538756(2021) [pubmed]

Zhang Y, Pan M, Li CY, Li JY, Ge W, Xu L, Xiao Y, Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. Bioengineered, 12(1):6831-6843(2021) [pubmed]

submitter keyword: colorectal cancer, colorectal adenoma, tubulovillous adenoma, high-grade neoplasia, carcinogenesis, quantitative proteomics

Wei Ge
contact affiliation	Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
contact email	gewei@ibms.cams.cn
lab head
Wei Ge
contact affiliation	Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
contact email	gewei@ibms.cams.cn
dataset submitter

iProX dataset URI