PXD023849

PXD023849 is an original dataset announced via ProteomeXchange.

Title	Proteomic and functional analysis identifies proteins related to embryonic development in decidua of patients with early recurrent miscarriage
Description	Recurrent miscarriage (RM) is the occurrence of repeated pregnancies that end in miscarriage of the fetus before 20 weeks of gestation. Recurrent miscarriages affect about 1-2% of couples trying to conceive; however, mechanisms leading to this complication are largely unknown. Our previous studies using comparative proteomics identified 314 differentially expressed proteins (DEPs) in placental villous. In this study, we identified 5479 proteins from a total of 34157 peptides in decidua of patients with early recurrent miscarriage. Further analysis identified 311 DEPs in the decidua tissue; 159 proteins showed the increased expression while 152 proteins showed decreased expression. These 311 proteins were further analyzed using Ingenuity Pathway Analysis (IPA). The results suggested that 50 DEPs could play important roles in the embryonic development. Furthermore, network analysis of the placental villous and decidua embryonic development DEPs was performed in STRING database to find the core gene. This study identifies several proteins that are specifically associated with embryonic development in decidua of patients with early recurrent miscarriage, these results provide new insights into potential biological mechanisms and may ultimately inform recurrent miscarriage.
HostingRepository	PRIDE
AnnounceDate	2021-07-30
AnnouncementXML	Submission_2021-07-29_21:39:22.945.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hai-Tao Pan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-27 10:45:09	ID requested
⏵ 1	2021-07-29 21:39:23	announced

Xiong YM, Pan HT, Ding HG, He Y, Zhang J, Zhang F, Yu B, Zhang T, Huang HF, . Biol Reprod, 105(5):1246-1256(2021) [pubmed]

submitter keyword: Recurrent miscarriage

TMT

Decidua

IPA

Embryonic development

Hai-Tao Pan
contact affiliation	Shaoxing Maternity and Child Health Care Hospital, Shaoxing 312000, China.
contact email	panhaitao2007@163.com
lab head
Hai-Tao Pan
contact affiliation	Shaoxing Women and Children's Hospital, Shaoxing, China.
contact email	panhaitao2007@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD023849

PRIDE project URI

• PRIDE
  1. PXD023849
     1. Label: PRIDE project
     2. Name: Proteomic and functional analysis identifies proteins related to embryonic development in decidua of patients with early recurrent miscarriage