PXD023794

PXD023794 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Triazine pyridine chemistry for selective tyrosine labelling of proteins
Description	Chemoselective reactions allowing for amino acid-specific modification are essential for protein bioconjugation and covalent drug development. Apart from Lysine and Cysteine with superior nucleophilic side chains, other amino acid-selective reactions are also needed but not well developed. Herein, we report the development of the biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine-specific labelling under physiological conditions and profiling in whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems, displayed potentials in tyrosine-guided protein labelling, and had biocompatibility in living cells. The development of TPC based tyrosine labelling agents would offer additional tools in native protein chemical modification.
HostingRepository	MassIVE
AnnounceDate	2021-01-25
AnnouncementXML	Submission_2021-01-25_04:04:03.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhang Qing
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	unknown modification
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-25 03:35:35	ID requested
⏵ 1	2021-01-25 04:04:03	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Tyrosine labeling, Triazine-pyridine chemistry

submitter keyword: Tyrosine labeling, Triazine-pyridine chemistry

Contact List

Prof. Xuechen Li
contact affiliation	The University of Hong Kong
contact email	xuechenl@hku.hk
lab head
Zhang Qing
contact affiliation	The University of Hong Kong
contact email	zhangqing7864@163.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086762/