PXD023777 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic profiles of ZIKV-positive placentas of fetuses with microcephaly |
Description | Here we use a proteomic approach to study the role of the placenta in ZIKV-induced microcephaly and the mechanisms of ZIKV to cross the placental barrier. Samples were separated into three groups: an uninfected control group (ZIKV-CZS-), a group of placentas infected by ZIKV with normal neonates (ZIKV+CZS-), and a group of placentas infected by ZIKV that developed microcephaly in newborns (ZIKV+CZS+). Zika virus causes DNA damage and impairs gene expression and mRNA translation during infection of the placenta. Processes related to viral transcytosis, like endocytosis, autophagy and disruption of actin filament were also observed in CZS-infected placentas, which could lead to a higher virus infiltration. Unncontrolled maternal immune response as well as greater expression of cellular adhesion proteins in the decidua could lead to a disruption of tolerance during pregnancy and induction of neurological malformation of the neonates |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:48:04.438.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Proteomics Unit |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-25 00:14:29 | ID requested | |
1 | 2024-07-01 20:32:05 | announced | |
⏵ 2 | 2024-10-22 06:48:04 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
ProteomeXchange project tag: Human Proteome Project |
submitter keyword: Zika virus |
Proteomics |
microcephaly |
placenta |
immune response |
congenital Zika syndrome |
Contact List
Gilberto B. Domont |
contact affiliation | Proteomic Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveira Ramos, 149, CT- A-542, Cidade Universitária 21941-909 Rio de Janeiro, RJ, Brazil |
contact email | gilbertodomont@gmail.com |
lab head | |
Proteomics Unit |
contact affiliation | UFRJ |
contact email | unidadeproteomica@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023777
- Label: PRIDE project
- Name: Proteomic profiles of ZIKV-positive placentas of fetuses with microcephaly