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PXD023777

PXD023777 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic profiles of ZIKV-positive placentas of fetuses with microcephaly
DescriptionHere we use a proteomic approach to study the role of the placenta in ZIKV-induced microcephaly and the mechanisms of ZIKV to cross the placental barrier. Samples were separated into three groups: an uninfected control group (ZIKV-CZS-), a group of placentas infected by ZIKV with normal neonates (ZIKV+CZS-), and a group of placentas infected by ZIKV that developed microcephaly in newborns (ZIKV+CZS+). Zika virus causes DNA damage and impairs gene expression and mRNA translation during infection of the placenta. Processes related to viral transcytosis, like endocytosis, autophagy and disruption of actin filament were also observed in CZS-infected placentas, which could lead to a higher virus infiltration. Unncontrolled maternal immune response as well as greater expression of cellular adhesion proteins in the decidua could lead to a disruption of tolerance during pregnancy and induction of neurological malformation of the neonates
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:48:04.438.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterProteomics Unit
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-25 00:14:29ID requested
12024-07-01 20:32:05announced
22024-10-22 06:48:04announced2024-10-22: Updated project metadata.
Publication List
10.1002/PRCA.202100042;
Keyword List
ProteomeXchange project tag: Human Proteome Project
submitter keyword: Zika virus
Proteomics
microcephaly
placenta
immune response
congenital Zika syndrome
Contact List
Gilberto B. Domont
contact affiliationProteomic Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveira Ramos, 149, CT- A-542, Cidade Universitária 21941-909 Rio de Janeiro, RJ, Brazil
contact emailgilbertodomont@gmail.com
lab head
Proteomics Unit
contact affiliationUFRJ
contact emailunidadeproteomica@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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