PXD023777

PXD023777 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiles of ZIKV-positive placentas of fetuses with microcephaly
Description	Here we use a proteomic approach to study the role of the placenta in ZIKV-induced microcephaly and the mechanisms of ZIKV to cross the placental barrier. Samples were separated into three groups: an uninfected control group (ZIKV-CZS-), a group of placentas infected by ZIKV with normal neonates (ZIKV+CZS-), and a group of placentas infected by ZIKV that developed microcephaly in newborns (ZIKV+CZS+). Zika virus causes DNA damage and impairs gene expression and mRNA translation during infection of the placenta. Processes related to viral transcytosis, like endocytosis, autophagy and disruption of actin filament were also observed in CZS-infected placentas, which could lead to a higher virus infiltration. Unncontrolled maternal immune response as well as greater expression of cellular adhesion proteins in the decidua could lead to a disruption of tolerance during pregnancy and induction of neurological malformation of the neonates
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:48:04.438.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Unit
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-25 00:14:29	ID requested
1	2024-07-01 20:32:05	announced
⏵ 2	2024-10-22 06:48:04	announced	2024-10-22: Updated project metadata.

10.1002/PRCA.202100042;

ProteomeXchange project tag: Human Proteome Project

submitter keyword: Zika virus

Proteomics

microcephaly

placenta

immune response

congenital Zika syndrome

Gilberto B. Domont
contact affiliation	Proteomic Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveira Ramos, 149, CT- A-542, Cidade Universitária 21941-909 Rio de Janeiro, RJ, Brazil
contact email	gilbertodomont@gmail.com
lab head
Proteomics Unit
contact affiliation	UFRJ
contact email	unidadeproteomica@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD023777

PRIDE project URI

• PRIDE
  1. PXD023777
     1. Label: PRIDE project
     2. Name: Proteomic profiles of ZIKV-positive placentas of fetuses with microcephaly