PXD023776

PXD023776 is an original dataset announced via ProteomeXchange.

Title	Amniotic fluid proteomics in Congenital Zika Syndrome
Description	In this study, we analyzed by a shotgun proteomic approach the amniotic fluid of pregnant women infected with Zika carrying microcephalic (ZIKV+M+) or healthy fetuses (ZIKV+M-) compared to Zika negative controls (ZIKV-M-) to identify and understand the biological process and pathways affected by CZS development. Up-abundant proteins in the ZIKV+M- group showed enrichment mainly in the extracellular matrix (ECM) structure and organization. The innate immune system (i.e. neutrophil degranulation) and fibrin clot formation processes were dysregulated in the ZIKV+M+ group, with an increase in the abundance of proteins associated with these biological processes. In both groups, a decrease in the abundance of proteins associated with neutrophil degranulation was observed. ZIKV+M+ group presented a decrease of abundance in the dysregulated extracellular matrix proteins compared to ZIKV+M-. These results could suggest that the development of microcephalic or healthy phenotypes is more associated with the ECM and immune system protein abundances than the dysregulated processes in each group.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:48:04.459.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Unit
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-25 00:14:17	ID requested
1	2024-07-01 20:27:12	announced
⏵ 2	2024-10-22 06:48:04	announced	2024-10-22: Updated project metadata.

10.1002/PRCA.202100041;

ProteomeXchange project tag: Human Proteome Project

submitter keyword: Zika virus

Proteomics

microcephaly

amniotic fluid

neutrophil degranulation

extracellular matrix

Gillberto B. Domont
contact affiliation	Proteomic Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveira Ramos, 149, CT- A-542, Cidade Universitária 21941-909 Rio de Janeiro, RJ, Brazil
contact email	gilbertodomont@gmail.com
lab head
Proteomics Unit
contact affiliation	UFRJ
contact email	unidadeproteomica@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD023776

PRIDE project URI

• PRIDE
  1. PXD023776
     1. Label: PRIDE project
     2. Name: Amniotic fluid proteomics in Congenital Zika Syndrome