PXD023731

PXD023731 is an original dataset announced via ProteomeXchange.

Title	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
Description	Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionin beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (HRR2RRS) synthesis in the liver. This investigation provides novel evidence that14T sub-chronic administration of 4T14TKRG can elevate HRR2RRS production by increasing protein expression of CBS and CSE in the liver.
HostingRepository	PRIDE
AnnounceDate	2021-09-10
AnnouncementXML	Submission_2021-09-10_00:12:37.749.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ann-Yae Na
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-21 02:44:14	ID requested
⏵ 1	2021-09-10 00:12:39	announced

Na AY, Jo JJ, Kwon OK, Cho P, Gao Y, Kim JH, Kim KM, Ki SH, Lee S, Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis. Sci Rep, 11(1):12374(2021) [pubmed]

ProteomeXchange project tag: Toxicoproteomics (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Korean red ginseng

proteomics

cystathionin beta-synthase

cystathionine gamma- lyase

hydrogen sulfide

Sangkyu Lee
contact affiliation	Kyungpook national university
contact email	pharm239@gmail.com
lab head
Ann-Yae Na
contact affiliation	kyungpook national university
contact email	cpblady@hanmail.net
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023731
     1. Label: PRIDE project
     2. Name: Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis