PXD023726

PXD023726 is an original dataset announced via ProteomeXchange.

Title	SWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis
Description	Streptococcus suis is a significant cause of bacterial meningitis in humans, particularly in S.E. Asia, and is a leading cause of respiratory and invasive disease in pigs. Phase-variable DNA methyltransferases, associated with Restriction-Modification (R-M) systems, are a source of epigenetic gene regulation, controlling the expression of multiple genes throughout the genome. These systems are known as phasevarions (phase-variable regulons), and have been characterised in many host-adapted bacterial pathogens. We recently established the presence of a Type III DNA methyltransferase in S. suis (ModS), of which two alleles were described, ModS1 and ModS2. Strains which expressed either ModS1 or ModS2 exhibited differential methylation throughout the genome when compared with strains which did not. This altered methylation resulted in changes to gene expression and this SWATH-MS dataset demonstrates the resulting changes to protein expression as a result of the of ModS1 and ModS2. This dataset represents triplicate repeats from strains which express ModS (ON) and strains which do not (OFF).
HostingRepository	PRIDE
AnnounceDate	2021-04-26
AnnouncementXML	Submission_2021-04-25_21:29:33.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Greg Tram
SpeciesList	scientific name: Streptococcus suis; NCBI TaxID: 1307;
ModificationList	No PTMs are included in the dataset
Instrument	SCIEX instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-21 01:22:58	ID requested
⏵ 1	2021-04-25 21:29:33	announced

Dataset with its publication pending

submitter keyword: microbiology, SWATH-MS, Streptococcus suis

John Atack
contact affiliation	Institute for Glycomics, Griffith University
contact email	j.atack@griffith.edu.au
lab head
Greg Tram
contact affiliation	Institute for Glycomics, Griffith University
contact email	g.tram@griffith.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD023726

PRIDE project URI

• PRIDE
  1. PXD023726
     1. Label: PRIDE project
     2. Name: SWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis