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PXD023726

PXD023726 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis
DescriptionStreptococcus suis is a significant cause of bacterial meningitis in humans, particularly in S.E. Asia, and is a leading cause of respiratory and invasive disease in pigs. Phase-variable DNA methyltransferases, associated with Restriction-Modification (R-M) systems, are a source of epigenetic gene regulation, controlling the expression of multiple genes throughout the genome. These systems are known as phasevarions (phase-variable regulons), and have been characterised in many host-adapted bacterial pathogens. We recently established the presence of a Type III DNA methyltransferase in S. suis (ModS), of which two alleles were described, ModS1 and ModS2. Strains which expressed either ModS1 or ModS2 exhibited differential methylation throughout the genome when compared with strains which did not. This altered methylation resulted in changes to gene expression and this SWATH-MS dataset demonstrates the resulting changes to protein expression as a result of the of ModS1 and ModS2. This dataset represents triplicate repeats from strains which express ModS (ON) and strains which do not (OFF).
HostingRepositoryPRIDE
AnnounceDate2021-04-26
AnnouncementXMLSubmission_2021-04-25_21:29:33.186.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGreg Tram
SpeciesList scientific name: Streptococcus suis; NCBI TaxID: 1307;
ModificationListNo PTMs are included in the dataset
InstrumentSCIEX instrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-21 01:22:58ID requested
12021-04-25 21:29:33announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: microbiology, SWATH-MS, Streptococcus suis
Contact List
John Atack
contact affiliationInstitute for Glycomics, Griffith University
contact emailj.atack@griffith.edu.au
lab head
Greg Tram
contact affiliationInstitute for Glycomics, Griffith University
contact emailg.tram@griffith.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
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