PXD023726 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis |
Description | Streptococcus suis is a significant cause of bacterial meningitis in humans, particularly in S.E. Asia, and is a leading cause of respiratory and invasive disease in pigs. Phase-variable DNA methyltransferases, associated with Restriction-Modification (R-M) systems, are a source of epigenetic gene regulation, controlling the expression of multiple genes throughout the genome. These systems are known as phasevarions (phase-variable regulons), and have been characterised in many host-adapted bacterial pathogens. We recently established the presence of a Type III DNA methyltransferase in S. suis (ModS), of which two alleles were described, ModS1 and ModS2. Strains which expressed either ModS1 or ModS2 exhibited differential methylation throughout the genome when compared with strains which did not. This altered methylation resulted in changes to gene expression and this SWATH-MS dataset demonstrates the resulting changes to protein expression as a result of the of ModS1 and ModS2. This dataset represents triplicate repeats from strains which express ModS (ON) and strains which do not (OFF). |
HostingRepository | PRIDE |
AnnounceDate | 2021-04-26 |
AnnouncementXML | Submission_2021-04-25_21:29:33.186.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Greg Tram |
SpeciesList | scientific name: Streptococcus suis; NCBI TaxID: 1307; |
ModificationList | No PTMs are included in the dataset |
Instrument | SCIEX instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-21 01:22:58 | ID requested | |
⏵ 1 | 2021-04-25 21:29:33 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: microbiology, SWATH-MS, Streptococcus suis |
Contact List
John Atack |
contact affiliation | Institute for Glycomics, Griffith University |
contact email | j.atack@griffith.edu.au |
lab head | |
Greg Tram |
contact affiliation | Institute for Glycomics, Griffith University |
contact email | g.tram@griffith.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD023726 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023726
- Label: PRIDE project
- Name: SWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis