PXD023724

PXD023724 is an original dataset announced via ProteomeXchange.

Title	Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart
Description	Understanding the molecular mechanisms underlying age-related changes in the heart is challenging due to the contributions from numerous genetic and environmental factors. Genetically diverse outbred mice provide a model to study the genetic regulation of aging processes in healthy tissues from individuals undergoing natural aging in a controlled environment. We analyzed transcriptome and proteome data from outbred mice at 6, 12 and 18 months of age to reveal a scenario of cardiac hypertrophy, fibrosis, extracellular matrix remodeling, and reemergence of fetal gene expression patterns. We observed widespread changes in protein trafficking and sorting, and post-translational disruption of the stoichiometry of the protein quality control system itself. We identified genome hotspots of age-by-genetic effects that regulate proteins from the proteasome and endoplasmic reticulum stress response, suggesting that genetic variation in these modules may contribute to individual variation in the aging heart.
HostingRepository	PRIDE
AnnounceDate	2021-12-23
AnnouncementXML	Submission_2021-12-23_11:15:54.877.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joel Chick
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-21 01:22:58	ID requested
⏵ 1	2021-12-23 11:15:55	announced

Dataset with its publication pending

submitter keyword: QTL, Proteomics, Ageing, Heart

Steven Gygi
contact affiliation	Department of Cell Biology, Harvard Medical School, Boston, MA
contact email	steven_gygi@hms.harvard.edu
lab head
Joel Chick
contact affiliation	Harvard Medical School
contact email	chick.joel@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023724
     1. Label: PRIDE project
     2. Name: Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart