PXD023677

PXD023677 is an original dataset announced via ProteomeXchange.

Title	Label-free quantification of proteins in wild type and CLPP-null mouse embryonic fibroblasts
Description	We studied consequences of genetic deletion of mitochondrial peptidase CLPP for global proteome profile in unstressed cells.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_14:04:06.999.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-19 22:09:40	ID requested
⏵ 1	2022-02-16 14:04:07	announced

Key J, Torres-Odio S, Bach NC, Gispert S, Koepf G, Reichlmeir M, West AP, Prokisch H, Freisinger P, Newman WG, Shalev S, Sieber SA, Wittig I, Auburger G, Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA. Cells, 10(12):(2021) [pubmed]

submitter keyword: LC-MSMS, mitochondrial accumulation of ribosomes and nucleoids, VDAC-dependent release, cGAS-STING-IRF7-IFNB-STAT1 activation, basal innate immunity elevation, antiviral state

Georg Auburger
contact affiliation	Experimental Neurology, Medical Faculty, Goethe University, Frankfurt am Main, Germany
contact email	auburger@em.uni-frankfurt.de
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD023677

PRIDE project URI

• PRIDE
  1. PXD023677
     1. Label: PRIDE project
     2. Name: Label-free quantification of proteins in wild type and CLPP-null mouse embryonic fibroblasts