PXD023598

PXD023598 is an original dataset announced via ProteomeXchange.

Title	PP1 inhibition using 1E7-03 during Human Cytomegalovirus infection in foreskin fibroblasts
Description	Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins in its tegument layer for a rapid supply upon infection. However, the biological relevance behind PP1 incorporation and release upon infection is unclear. Additionally, PP1 is a difficult molecular target due to its promiscuity and similarities between the catalytic domain of multiple phosphatases. In this study, we circumvented these shortcomings by using 1E7-03, a small molecule protein-protein interaction inhibitor, as a molecular tool of noncatalytic PP1 inhibition in CMV infection.
HostingRepository	PRIDE
AnnounceDate	2021-06-03
AnnouncementXML	Submission_2021-06-03_07:59:50.325.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carmen Stecher
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-14 07:53:31	ID requested
⏵ 1	2021-06-03 07:59:50	announced

Dataset with its publication pending

submitter keyword: Human, CMV, HCMV, PP1

Christoph Steininger
contact affiliation	Department of Internal Medicine I Division of Infectious Diseases Medical University of Vienna, Austria
contact email	christoph.steininger@meduniwien.ac.at
lab head
Carmen Stecher
contact affiliation	Medical University of Vienna
contact email	carmen.stecher@muv.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD023598

PRIDE project URI

• PRIDE
  1. PXD023598
     1. Label: PRIDE project
     2. Name: PP1 inhibition using 1E7-03 during Human Cytomegalovirus infection in foreskin fibroblasts