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PXD023586

PXD023586 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAP-MS of helicase Upf1 in PC12 cells
DescriptionDNA/RNA helicase Upf1 seems to interact with axonal transcripts in response to nerve growth factor (NGF, A. Ludanyi, M. Gaspari and A. Riccio, unpublished data). In order to shed light on Upf1 mechanism of action and to identify potential associations with molecules having cleavage activity, we performed an AP-MS experiment comprising Upf1 immunoprecipitation, on-beads digestion, isotopic labelling (18O) and quantitative LC-MS/MS analysis.
HostingRepositoryPRIDE
AnnounceDate2021-09-10
AnnouncementXMLSubmission_2021-09-09_16:12:21.670.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarco Gaspari
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList(18)O label at both C-terminal oxygens
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-14 01:49:35ID requested
12021-09-09 16:12:22announced
Publication List
Andreassi C, Luisier R, Crerar H, Darsinou M, Blokzijl-Franke S, Lenn T, Luscombe NM, Cuda G, Gaspari M, Saiardi A, Riccio A, Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity. Cell Rep, 34(8):108778(2021) [pubmed]
Keyword List
submitter keyword: Protein complex, IMPA1, HuD, Ago2
Contact List
Marco Gaspari
contact affiliationDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy
contact emailgaspari@unicz.it
lab head
Marco Gaspari
contact affiliationUniversity of Catanzaro
contact emailgaspari@unicz.it
dataset submitter
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Dataset FTP location
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PRIDE project URI
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