PXD023531

PXD023531 is an original dataset announced via ProteomeXchange.

Title	Time-series proteomics and phosphoproteomics analysis of human airway epithelial cells in the absence or presence of a specific IKK inhibitor
Description	Epithelial-mesenchymal transition (EMT) plays a critical role in airway injury, repair, and structural remodeling. Although NFkB/RelA subnit is involved in late EMT-associated gene expression, RelA translocation is occurs later than early phases of IκB kinase (IKK)-depenedent gene expression. To investigate the hypothesis that IKK plays an independent mechanism in TGF-induced EMT, we conducted time-series proteomics and phosphoproteomics analysis of human airway epithelial cells in the absence or presence of a specific IKK inhibitor, BMS -345541.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:09:35.500.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingxin Zhao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-11 10:43:50	ID requested
1	2022-10-13 21:29:20	announced
⏵ 2	2023-11-14 08:09:41	announced	2023-11-14: Updated project metadata.

Zhao Y, Zhang J, Sun H, Brasier AR, B Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition. J Proteome Res, 20(7):3475-3488(2021) [pubmed]

submitter keyword: proteomics, IκB kinase-NFκB, and hexosamine biosynthesis pathway, N-glycosylation,epithelial-mesenchymal transition, unfolded protein response, extracellular matrix

Yingxin Zhao, Ph.D.
contact affiliation	University of Texas Medical Branch
contact email	yizhao@utmb.edu
lab head
Yingxin Zhao
contact affiliation	University of Texas Medical Branch
contact email	yizhao@utmb.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD023531

PRIDE project URI

• PRIDE
  1. PXD023531
     1. Label: PRIDE project
     2. Name: Time-series proteomics and phosphoproteomics analysis of human airway epithelial cells in the absence or presence of a specific IKK inhibitor