PXD023526

PXD023526 is an original dataset announced via ProteomeXchange.

Title	Pilot proteomic profiling of blood plasma obtained from lean and obese individuals
Description	Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of “cheap calories” are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in development of early-stage obesity biomarkers, allowing distinguish between metabolic syndromes and anti-obesity targets. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy.
HostingRepository	PRIDE
AnnounceDate	2021-09-10
AnnouncementXML	Submission_2021-09-09_16:41:16.917.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Olga Kiseleva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-pyridylethyl-L-cysteine; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-11 10:42:26	ID requested
⏵ 1	2021-09-09 16:41:17	announced

Kiseleva OI, Arzumanian VA, Poverennaya EV, Pyatnitskiy MA, Ilgisonis EV, Zgoda VG, Plotnikova OA, Sharafetdinov KK, Lisitsa AV, Tutelyan VA, Nikityuk DB, Archakov AI, Ponomarenko EA, Does Proteomic Mirror Reflect Clinical Characteristics of Obesity? J Pers Med, 11(2):(2021) [pubmed]

submitter keyword: blood plasma, obese, lean, metabolic syndrome, LC-MS/MS

Ekaterina Poverennaya
contact affiliation	Laboratory of Interactomics of Proteoforms, Institute of Biomedical Chemistry
contact email	k.poverennaya@gmail.com
lab head
Olga Kiseleva
contact affiliation	Institute of Biomedical Chemistry
contact email	olly.kiseleva@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD023526

PRIDE project URI

• PRIDE
  1. PXD023526
     1. Label: PRIDE project
     2. Name: Pilot proteomic profiling of blood plasma obtained from lean and obese individuals