PXD023474
PXD023474 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis in the study of the mitochondrial supercomplex assembly |
Description | Mitochondrial supercomplexes are functionally important, but how supercomplexes being assembled is not known. Mitochondrial Complex I has an important role in the assembly of supercomplex. In this study, we generated a series of cell model with shRNA mediated gene silencing or CRISPR-Cas9 gene knockout technology. We performed a series of mitochondrial proteome analyses in different cell lines with disruption of gene that encodes subunit of Complex I. Also, we performed Co-IP of exogenous TIMMDC1, which was an assembly factor of Complex I. |
HostingRepository | iProX |
AnnounceDate | 2021-01-08 |
AnnouncementXML | Submission_2022-09-21_23:10:48.519.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xianglai Ye |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion; Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-01-08 04:06:07 | ID requested | |
⏵ 1 | 2022-09-21 23:10:49 | announced |
Publication List
Keyword List
submitter keyword: mitochondria, supercomplex assembly, mitochondrial proteomics, Co-IP |
Contact List
Jianxin Lyu | |
---|---|
contact affiliation | Wenzhou Medical University |
contact email | jxlu313@163.com |
lab head | |
Xianglai Ye | |
contact affiliation | Wenzhou Medical University |
contact email | xlye96@outlook.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |