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PXD023457

PXD023457 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of U251 MG glioblastoma cells in the presence and absence of α-fodrin
DescriptionThe cortical cytoskeleton comprises mainly of the spectrin family of proteins. Spectrin and fodrin are members of this family. They support the plasma membrane. Fodrin is expressed in most tissues apart from the erythrocytes. Fodrin has been shown to be important in a wide variety of functions such as signal transduction, cardiac and brain development, etc. Through our studies it was understood that fodrin not only serves as a cortical supporting protein, but it also interacts with γ-tubulin and inhibits its microtubule nucleation activity. To gain a comprehensive view on the diverse functions of fodrin it was imperative to look into the downstream effectors of this protein in an unbiased fashion. Hence, we decided to downregulate α-fodrin in glioblastoma cells U-251 MG, and then perform a global protein expression analysis.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:22:14.265.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD023457
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMAHESH CHANDRAN V R
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListL-methionine sulfone; S-carboxamidomethyl-L-cysteine
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-07 06:37:37ID requested
12021-05-24 06:41:29announced
22024-10-22 05:22:14announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD023457;
Keyword List
submitter keyword: α-fodrin,LC-MS,shRNA,U251 MG glioblastoma cells
Contact List
Dr.Suparna sengupta
contact affiliationscientist F Rajiv Gandhi Centre for Biotechnology
contact emailssengupta@rgcb.res.in
lab head
MAHESH CHANDRAN V R
contact affiliationTechnician, Mass spectrometry and proteomics core facility, RGCB
contact emailmaheshchandran@rgcb.res.in
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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