PXD023423

PXD023423 is an original dataset announced via ProteomeXchange.

Title	Mining gastric cancer cellular quantitative proteomics data to analyse the proteome change upon CAMKK2 inhibition
Description	Gastric cancer is a global health concern. Molecular alterations in various signaling pathways have been implicated in the development and late-stage progression/metastasis of gastric cancer. Reports have suggested that Wnt signaling pathway might contribute to gastric carcinogenesis by stimulating migration and invasion of gastric cancer cells. This study aimed at analysing the proteome change upon CAMKK2 inhibition in gastric cancer cells using LC-MS/MS based quantitative proteomic approach. A TMT based quantitative approach was used to identify the significantly altered proteins upon CAMKK2 inhibition. Gene Ontology (GO) analysis and pathway analysis was done for the significantly altered proteins and was later validated by immunoblotting.
HostingRepository	PRIDE
AnnounceDate	2021-04-14
AnnouncementXML	Submission_2021-04-13_23:04:20.668.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aditi Chatterjee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-06 00:03:17	ID requested
⏵ 1	2021-04-13 23:04:21	announced

Najar MA, Modi PK, Ramesh P, Sidransky D, Gowda H, Prasad TSK, Chatterjee A, Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer. J Proteome Res, 20(5):2687-2703(2021) [pubmed]

submitter keyword: Gastric cancer, Proteomics, Data Mining, CAMKK2, STO-609, Mass spectrometry

Aditi Chatterjee
contact affiliation	Center for Systems Biology and Molecular Medicine (CSBMM) Yenepoya(Deemed to be University) Mangalore - 575018, India
contact email	aditixchatterjee@gmail.com
lab head
Aditi Chatterjee
contact affiliation	Institute of Bioinformatics, Bangalore, Karnataka, India
contact email	aditixchatterjee@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023423
     1. Label: PRIDE project
     2. Name: Mining gastric cancer cellular quantitative proteomics data to analyse the proteome change upon CAMKK2 inhibition