PXD023417

PXD023417 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of humoral immune components in bronchoalveolar lavage of patients infected or colonized by Aspergillus fumigatus
Description	Humoral immune factors have been individually studied in the context of host-Aspergillus fumigatus interaction. However, a global view of the multitude and complex nature of humoral factors is needed to bring new insight into the pathobiology of aspergillosis. Therefore, we undertook proteomic analysis of A. fumigatus-infected or colonized bronchoalveolar lavage fluid versus controls, to identify alveolar humoral factors affected upon A. fumigatus infection. Complement proteins C1q, C8 beta chain, factor-H, surfactant protein-D, ficolin-1, ficolin-2, mannan binding lectin serine peptidase 2 and pentraxin-3 were identified as the major candidates. We hypothesize that crosstalk between these factors is essential during host-Aspergillus interaction.
HostingRepository	PRIDE
AnnounceDate	2021-08-11
AnnouncementXML	Submission_2021-08-11_01:28:15.014.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Magalie Duchateau
SpeciesList	scientific name: Aspergillus fumigatus Af293; NCBI TaxID: 330879; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-05 04:03:53	ID requested
⏵ 1	2021-08-11 01:28:15	announced

Delli, è, re S, Duchateau M, Wong SSW, Giai Gianetto Q, Guegan H, Matondo M, Gangneux JP, Aimanianda V, . Front Immunol, 12():677798(2021) [pubmed]

submitter keyword: Aspergillus fumigatus, bronchoalveolar lavage, alveolar humoral factors

Vishukumar Aimanianda
contact affiliation	Institut Pasteur Molecular Mycology Unit CNRS UMR2000 Paris, France
contact email	kumar-vishu.aimanianda-bopaiah@pasteur.fr
lab head
Magalie Duchateau
contact affiliation	Institut Pasteur
contact email	magalie.duchateau@pasteur.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD023417

PRIDE project URI

• PRIDE
  1. PXD023417
     1. Label: PRIDE project
     2. Name: Proteomic analysis of humoral immune components in bronchoalveolar lavage of patients infected or colonized by Aspergillus fumigatus