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PXD023379

PXD023379 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleN-Glycome and N-Glycoproteome of a Hematophagous Parasitic Nematode Haemonchus
DescriptionN-glycosylation is a physiologically vital post-translational modification of proteins in eukaryotic organisms. Initial work on Haemonchus contortus – an economically-important blood-sucking nematode of ruminants with a broad geographical distribution – has shown that the parasite harbors N-glycans with exclusive core chitobiose modifications, and severel immunogenic proteins (e.g., amino- and metallo-peptidases) in the adult worms are N-glycosylated. However, an informative atlas of N-glycosylation in H. contortus is not yet available. Herein, we report a total of 291 N-glycosylated proteins with 425 sites in this parasite. Functional analyses of glycoproteome revealed significant enrichment of the peptidase families (e.g., peptidase C1 and M1), many of which are potential vaccine targets. Besides, the glycan-rich conjugates are distributed primarily in the intestine and gonads of the adult worms. These data, taken together, provide a comprehensive insight into the N-glycosylation of a prevalent parasitic nematode, while underlining its significance for the infection and prophylaxis.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_15:47:21.676.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChunqun Wang
SpeciesList scientific name: Haemonchus contortus; NCBI TaxID: 6289;
ModificationListcomplex glycosylation
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-04 03:10:38ID requested
12021-09-09 15:47:22announced
Publication List
Wang C, Gao W, Yan S, Zhu XQ, Suo X, Liu X, Gupta N, Hu M, . Comput Struct Biotechnol J, 19():2486-2496(2021) [pubmed]
Keyword List
submitter keyword: Haemonchus contortus, N-glycosylation, N-glycan, mass spectrometry, glycopeptide
Contact List
Min Hu
contact affiliationState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University
contact emailmhu@mail.hzau.edu.cn
lab head
Chunqun Wang
contact affiliationState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University
contact emailwangchunqun@webmail.hzau.edu.cn
dataset submitter
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Dataset FTP location
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