PXD023305

PXD023305 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage
Description	The COVID-19 pandemic has become a world-wide health crisis. So far, most studies have focused on the epidemiology and pathogenesis of this infectious disease. Little attention has been paid to the disease sequelae in patients recovering from COVID-19, and nothing is known about the mechanisms underlying these sequelae. Herein, we profiled the serum proteome of a cohort of COVID-19 patients in the disease onset and recovery stages. Based on close integration of our proteomic analysis with clinical data, we propose that COVID-19 is associated with prolonged disorders in cholesterol metabolism and myocardium, even in the recovery stage. We identify potential biomarkers for these disorders. Moreover, severely affected patients presented more serious disturbances of these pathways. Our findings potentially support clinical decision-making to improve the prognosis and treatment of patients.
HostingRepository	iProX
AnnounceDate	2020-12-24
AnnouncementXML	Submission_2022-11-16_20:34:41.316.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuaixin Gao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	time-of-flight mass spectrometer

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-23 21:29:25	ID requested
⏵ 1	2022-11-16 20:34:42	announced

Chen Y, Yao H, Zhang N, Wu J, Gao S, Guo J, Lu X, Cheng L, Luo R, Liang X, Wong CCL, Zheng M, Proteomic Analysis Identifies Prolonged Disturbances in Pathways Related to Cholesterol Metabolism and Myocardium Function in the COVID-19 Recovery Stage. J Proteome Res, 20(7):3463-3474(2021) [pubmed]

submitter keyword: COVID-19, cholesterol metabolism, myocardium function

Catherine CL Wong
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	catherine_wong@bjmu.edu.cn
lab head
Shuaixin Gao
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	gaoshuaixin@126.com
dataset submitter

iProX dataset URI