PXD023301

PXD023301 is an original dataset announced via ProteomeXchange.

Title	Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand
Description	Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative disorder found in senior dogs. Due to the lack of biological markers, CCDS is commonly underdiagnosed. The aim of this study was to identify potential plasma biomarkers using proteomics techniques and to increase our understanding of the pathogenic mechanism of the disease. Plasma amyloid beta 42 (Aβ42) has been seen to be a controversial biomarker for CCDS. Proteomics analysis was performed for protein identification and quantification. The nano-LC-MS/MS data revealed that the predictive underlying mechanism of CCDS was the co-occurrence of inflammation-mediated acute phase response proteins and complement and coagulation cascades that partly functioned by apolipoproteins and lipid metabolism. Some of the differentially expressed proteins may serve as potential predictor biomarkers along with Aβ42 in plasma for improved CCDS diagnosis.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_15:37:16.831.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sataporn Phochantachinda
SpeciesList	scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker Daltonics micrOTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-23 07:20:22	ID requested
⏵ 1	2021-09-09 15:37:17	announced

Phochantachinda S, Chantong B, Reamtong O, Chatchaisak D, Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand. BMC Vet Res, 17(1):60(2021) [pubmed]

submitter keyword: Amyloid beta 42, Canine cognitive dysfunction syndrome, LC-MS/MS

Onrapak Reamtong
contact affiliation	Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
contact email	onrapak.rea@mahidol.edu
lab head
Sataporn Phochantachinda
contact affiliation	Faculty of Veterinary Science, Mahidol University
contact email	sataporn.pho@mahidol.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023301
     1. Label: PRIDE project
     2. Name: Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand