PXD023297 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway |
Description | By precisely dissected MS for proteomics, we found that donepezil remarkably restored (at high dose), even elevated (at low dose) the level of vacuolar protein sorting-associated protein 37D (VP37D), an autophagy-related protein, in hTauMS mice. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-09_15:37:01.497.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | haitao Yu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-23 05:28:58 | ID requested | |
⏵ 1 | 2021-09-09 15:37:03 | announced | |
Publication List
Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, Wang X, Liu E, Ye J, Yu H, Gao Y, He T, Jiang T, Sun F, Su J, Song G, Peng W, Yang Y, Wang JZ, Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clin Transl Med, 11(6):e428(2021) [pubmed] |
Keyword List
submitter keyword: Alzheimer’s disease, tau accumulation, medial septum, hippocampus, cholinergic neuron,mouse |
Contact List
Jian-zhi Wang |
contact affiliation | Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology |
contact email | wangjz@mail.hust.edu.cn |
lab head | |
haitao Yu |
contact affiliation | Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology |
contact email | 2647220207@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD023297 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023297
- Label: PRIDE project
- Name: Tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway