PXD023246

PXD023246 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling reveals the molecular changes of insomnia patients
Description	Insomnia is an economic burden and public health problem. This study aimed to explore potential biological pathways and protein networks for insomnia characterized by wakefulness after sleep. Proteomics analysis was performed in the insomnia group with wakefulness and the control group. The differentially expressed proteins (DEPs) were enriched, then hub proteins were identified by protein-protein interaction (PPI) network and verified by parallel reaction monitoring (PRM). Compared with the control group, the sleep time and efficiency of insomnia patients were decreased, awakening time and numbers after sleep onset were significantly increased (P < 0.001). The results of proteomic sequencing found 68 DEPs in serum under 1.2-fold changed standard. These DEPs were significantly enriched in humoral immune response, complement and coagulation cascades, cholesterol metabolism. Through PPI network, we identified 10 proteins with the highest connectivity as hub proteins. Among them, differential expression of 9 proteins was verified by PRM.We identified the hub proteins and molecular mechanisms of insomnia patients characterized by wakefulness after sleep. It provided potential molecular targets for the clinical diagnosis and treatment of these patients, and indicated the immune and metabolic systems may be closely related to insomnia characterized by wakefulness after sleep.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_12:24:28.567.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guanying Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-21 02:43:39	ID requested
⏵ 1	2022-02-16 12:24:29	announced

Wang G, Ren X, Zhang X, Wang Q, Liu T, Deng N, Yan D, Proteomic Profiling Reveals the Molecular Changes of Insomnia Patients. Biomed Res Int, 2021():6685929(2021) [pubmed]

submitter keyword: Insomnia

wakefulness

proteomics

immune response

metabolism

PRM

Guanying Wang
contact affiliation	Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University
contact email	915675629@qq.com
lab head
Guanying Wang
contact affiliation	Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University
contact email	915675629@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023246
     1. Label: PRIDE project
     2. Name: Proteomic profiling reveals the molecular changes of insomnia patients