PXD023201 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteogenomic pathogenesis and classification of acute myeloid leukemia (Discovery cohort) |
Description | Acute myeloid leukemia is a clinically and genetically heterogenous disease characterized by bone marrow infiltration with immature leukemic blasts that cause bone marrow failure. Patient age, comorbidities and genomic disease characteristics have a profound impact on patient outcome. Here, we present an integrated Multi-Omics analysis of protein and gene expression as well as cytogenetics and mutations to capture the rewiring of intracellular protein networks that is most likely caused by genomic aberrations. Because protein networks are downstream of genomic aberrations, we hypothesized that our Multi-Omics approach may add to the current AML classification by identifying proteomic AML subtypes with specific clinical and molecular features that could identify therapeutic vulnerabilities and aid in the identification of predictive biomarkers |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-08 |
AnnouncementXML | Submission_2022-03-08_03:53:54.204.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ashokkumar Jayavelu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-17 06:17:31 | ID requested | |
⏵ 1 | 2022-03-08 03:53:54 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: AML, Label free proteome, DIA |
Contact List
Prof.Matthias Mann |
contact affiliation | MaxPlanck Insitute of Biochemistry Department of Proteomics and Signal transduction |
contact email | mmann@biochem.mpg.de |
lab head | |
Ashokkumar Jayavelu |
contact affiliation | Dept Proteomics and Signal Transduction, MaxPlanck Institute of Biochemistry |
contact email | jayavelu@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD023201 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023201
- Label: PRIDE project
- Name: Proteogenomic pathogenesis and classification of acute myeloid leukemia (Discovery cohort)