PXD023083

PXD023083 is an original dataset announced via ProteomeXchange.

Title	A viral protein disturb nucleocytoplasmic shuttling of TaSRT2 activating plant immunity by increasing histone acetylation
Description	Plant immune responses to pathogen infection require the elaborate transcriptome reprogramming. Histone acetylation is known to play important roles during host-pathogen interactions. However, how plants employ these processes against viral infections remains largely unknown. Here, we discovered that hyperacetylation/hypoacetylation of histone H3 can inhibit/enhance Chinese Wheat Mosaic Virus (CWMV) infection in wheat, and confirmed that TaSRT2 interacts with P153. The TaSRT2-P153 interaction prevents the shuttling of TaSRT2 from the cytoplasm into the nucleus, and this restricts TaSRT2 deacetylation of H3K9ac and H3K79ac, allowing the modulation of TaSRT2-mediated immune responses such as the induction expression of resistance-related genes to intensify the plant basal defense against the CWMV infection. Importantly, the 322 to 332 amino acids in TaSRT2 influenced the interaction between TaSRT2 and P153. Our results discover an effective immune mechanism by which SRT2 interacts with viral proteins to activate the host basal resistance through inhibiting the function of deacetylases during viral infection.
HostingRepository	PRIDE
AnnounceDate	2021-05-07
AnnouncementXML	Submission_2021-05-06_22:54:35.299.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kaili Zhong
SpeciesList	scientific name: Triticum aestivum (Wheat); NCBI TaxID: 4565;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-12 11:38:19	ID requested
⏵ 1	2021-05-06 22:54:35	announced

Dataset with its publication pending

submitter keyword: Chinese wheat mosaic virus

H3

Acetylation

Pathoen infection

Wheat defense

Kaili Zhong
contact affiliation	Ningbo University
contact email	zhongkaili@nbu.edu.cn
lab head
Kaili Zhong
contact affiliation	Ningbo University
contact email	zhongkaili@nbu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023083
     1. Label: PRIDE project
     2. Name: A viral protein disturb nucleocytoplasmic shuttling of TaSRT2 activating plant immunity by increasing histone acetylation