PXD023078

PXD023078 is an original dataset announced via ProteomeXchange.

Title	A chromatin basis for protein-RNA correlation in human cancer
Description	This work describes a previously unreported link between the chromatin states and protein abundance in cancer. We curated and studied a novel cohort of human thyroid tumors that allowed us to identify chromatin features that directly regulate protein expression. We believe this is the first study to establish chromatin states that reflect protein abundances in human cancer.
HostingRepository	PRIDE
AnnounceDate	2021-11-02
AnnouncementXML	Submission_2021-11-02_06:06:58.108.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akshay Sanghi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-11 08:44:08	ID requested
⏵ 1	2021-11-02 06:06:58	announced

Sanghi A, Gruber JJ, Metwally A, Jiang L, Reynolds W, Sunwoo J, Orloff L, Chang HY, Kasowski M, Snyder MP, Chromatin accessibility associates with protein-RNA correlation in human cancer. Nat Commun, 12(1):5732(2021) [pubmed]

submitter keyword: Human cancer, proteomics MS/MS, systems biology

Michael Snyder
contact affiliation	Department of Genetics, Stanford University
contact email	mpsnyder@stanford.edu
lab head
Akshay Sanghi
contact affiliation	Stanford University
contact email	asanghi@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD023078

PRIDE project URI

• PRIDE
  1. PXD023078
     1. Label: PRIDE project
     2. Name: A chromatin basis for protein-RNA correlation in human cancer