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PXD023009

PXD023009 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder
DescriptionPurpose There are great demands for identifying markers of major depressive disorder (MDD), which is a common mental illness with a prevalence of approximately 6%. Finding potential markers to aid MDD diagnosis is in high demand. Experimental design In this study, combination of the salt-out assisted liquid-liquid extraction (SALLE) pretreatment method and a nontargeted peptidomics approach based on nano-LC-Orbitrap/MS is primarily employed to discover the candidate peptide biomarkers from the plasma of 238 subjects. Results A large number of peptides are enriched and identified from the plasma samples, of which 42 peptides show significant differences between MDD patients and controls by univariate statistical analysis. A diagnostic model combined four peptide markers (P1, P9, P17, P29) is established by binary logistic regression analysis, yielding an overall prediction accuracy of 91.7% and 82.2% in the discovery and validation sets, respectively. Conclusions and clinical relevance In conclusion, the good performance of diagnostic model in both discovery and validation sets demonstrates the robustness of peptide markers panel. It is very valuable for quantification the absolute content of four peptides and further verification.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:44:50.722.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD023009
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitteryi wang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListamidated residue; dehydrated residue; phosphorylated residue; homoserine; acetylated residue; monohydroxylated residue; deamidated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-12-09 00:29:58ID requested
12023-04-13 08:40:20announced
22023-11-14 08:44:51announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD023009;
Wang Y, Liu X, Liu D, Cheng M, Zhao N, He M, Zhang X, Plasma nontargeted peptidomics discovers potential biomarkers for major depressive disorder. Proteomics Clin Appl, 15(6):e2000058(2021) [pubmed]
Keyword List
submitter keyword: peptidomics, major depressive disorder,biomarkers, plasma, diagnostic model
Contact List
Yi Wang
contact affiliationuniversity of chinese academy of sciences
contact emailwangyiwy@dicp.ac.cn
lab head
yi wang
contact affiliationChinese academy of sciences
contact emailwangyiwy@dicp.ac.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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Repository Record List
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