PXD023009

PXD023009 is an original dataset announced via ProteomeXchange.

Title	Plasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder
Description	Purpose There are great demands for identifying markers of major depressive disorder (MDD), which is a common mental illness with a prevalence of approximately 6%. Finding potential markers to aid MDD diagnosis is in high demand. Experimental design In this study, combination of the salt-out assisted liquid-liquid extraction (SALLE) pretreatment method and a nontargeted peptidomics approach based on nano-LC-Orbitrap/MS is primarily employed to discover the candidate peptide biomarkers from the plasma of 238 subjects. Results A large number of peptides are enriched and identified from the plasma samples, of which 42 peptides show significant differences between MDD patients and controls by univariate statistical analysis. A diagnostic model combined four peptide markers (P1, P9, P17, P29) is established by binary logistic regression analysis, yielding an overall prediction accuracy of 91.7% and 82.2% in the discovery and validation sets, respectively. Conclusions and clinical relevance In conclusion, the good performance of diagnostic model in both discovery and validation sets demonstrates the robustness of peptide markers panel. It is very valuable for quantification the absolute content of four peptides and further verification.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:44:50.722.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD023009
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	yi wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; dehydrated residue; phosphorylated residue; homoserine; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-09 00:29:58	ID requested
1	2023-04-13 08:40:20	announced
⏵ 2	2023-11-14 08:44:51	announced	2023-11-14: Updated project metadata.

10.6019/PXD023009;

Wang Y, Liu X, Liu D, Cheng M, Zhao N, He M, Zhang X, Plasma nontargeted peptidomics discovers potential biomarkers for major depressive disorder. Proteomics Clin Appl, 15(6):e2000058(2021) [pubmed]

submitter keyword: peptidomics, major depressive disorder,biomarkers, plasma, diagnostic model

Yi Wang
contact affiliation	university of chinese academy of sciences
contact email	wangyiwy@dicp.ac.cn
lab head
yi wang
contact affiliation	Chinese academy of sciences
contact email	wangyiwy@dicp.ac.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023009
     1. Label: PRIDE project
     2. Name: Plasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder