PXD023009 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder |
Description | Purpose There are great demands for identifying markers of major depressive disorder (MDD), which is a common mental illness with a prevalence of approximately 6%. Finding potential markers to aid MDD diagnosis is in high demand. Experimental design In this study, combination of the salt-out assisted liquid-liquid extraction (SALLE) pretreatment method and a nontargeted peptidomics approach based on nano-LC-Orbitrap/MS is primarily employed to discover the candidate peptide biomarkers from the plasma of 238 subjects. Results A large number of peptides are enriched and identified from the plasma samples, of which 42 peptides show significant differences between MDD patients and controls by univariate statistical analysis. A diagnostic model combined four peptide markers (P1, P9, P17, P29) is established by binary logistic regression analysis, yielding an overall prediction accuracy of 91.7% and 82.2% in the discovery and validation sets, respectively. Conclusions and clinical relevance In conclusion, the good performance of diagnostic model in both discovery and validation sets demonstrates the robustness of peptide markers panel. It is very valuable for quantification the absolute content of four peptides and further verification. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:44:50.722.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD023009 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | yi wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | amidated residue; dehydrated residue; phosphorylated residue; homoserine; acetylated residue; monohydroxylated residue; deamidated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-09 00:29:58 | ID requested | |
1 | 2023-04-13 08:40:20 | announced | |
⏵ 2 | 2023-11-14 08:44:51 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD023009; |
Wang Y, Liu X, Liu D, Cheng M, Zhao N, He M, Zhang X, Plasma nontargeted peptidomics discovers potential biomarkers for major depressive disorder. Proteomics Clin Appl, 15(6):e2000058(2021) [pubmed] |
Keyword List
submitter keyword: peptidomics, major depressive disorder,biomarkers, plasma, diagnostic model |
Contact List
Yi Wang |
contact affiliation | university of chinese academy of sciences |
contact email | wangyiwy@dicp.ac.cn |
lab head | |
yi wang |
contact affiliation | Chinese academy of sciences |
contact email | wangyiwy@dicp.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023009
- Label: PRIDE project
- Name: Plasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder