PXD022991

PXD022991 is an original dataset announced via ProteomeXchange.

Title	In vivo protein-protein crosslinking in human lens through lys or protein N-terminus with Gln/Glu residues
Description	In this study we identified protein-protein crosslinking through lys or protein N-terminus with Gln/Glu residues in aged human lens tissues. Such crosslinks could be reproduced experimentally by incubation of Glu- or Gln-containing peptides and their formation were consistent with an amino group attacking a glutarimide intermediate.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:53:26.694.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhen Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-08 02:24:56	ID requested
1	2023-08-01 13:35:43	announced
⏵ 2	2023-11-14 06:53:27	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: human lens, glutarimide, protein-protein crosslinking

Kevin L Schey
contact affiliation	Vanderbilt University
contact email	k.schey@vanderbilt.edu
lab head
Zhen Wang
contact affiliation	Vanderbilt University
contact email	zhen.wang@vanderbilt.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD022991

PRIDE project URI

• PRIDE
  1. PXD022991
     1. Label: PRIDE project
     2. Name: In vivo protein-protein crosslinking in human lens through lys or protein N-terminus with Gln/Glu residues