PXD022984

PXD022984 is an original dataset announced via ProteomeXchange.

Title	Nab2 Drosophila pupal brain LC-MSMS
Description	We exploit the predictable time course of Drosophila brain development to perform a temporally coupled quantitative proteomic analysis of the pupal brain in Nab2 mutant or overexpression models, which reveals that Nab2 is required to regulate the abundance of a number of proteins with critical roles in Drosophila neurons. Pupal brains lacking Nab2 show dysregulation of proteins, such as Futsch, Turtle, Contactin, and Van Gogh, that typically function in brain morphogenesis, neuroblast proliferation, circadian sleep/wake cycle, and other neurodevelopmental processes. Overall, these data define a role for Nab2 during neurodevelopment in regulating protein abundance for a subset of the brain proteome and provide a window into the potential functions of human ZC3H14 protein.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_03:38:46.588.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Edwin Corgiat
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-07 23:22:42	ID requested
⏵ 1	2022-02-17 03:38:47	announced

Corgiat EB, List SM, Rounds JC, Corbett AH, Moberg KH, developing Drosophila brain. J Biol Chem, 297(1):100877(2021) [pubmed]

submitter keyword: LC-MSMS, Drosophila melanogaster, Nab2

Kenneth H Moberg
contact affiliation	Department of Cell Biology, Emory University School of Medicine, Emory University, Atlanta, GA 30322 USA
contact email	kmoberg@emory.edu
lab head
Edwin Corgiat
contact affiliation	Emory University
contact email	ecorgia@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD022984

PRIDE project URI

• PRIDE
  1. PXD022984
     1. Label: PRIDE project
     2. Name: Nab2 Drosophila pupal brain LC-MSMS