PXD022974

PXD022974 is an original dataset announced via ProteomeXchange.

Title	Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair
Description	Emerging evidence points to post translational modification (PTM) of nuclear lamins as a key regulator of their diverse roles in nuclear organization, chromatin stability, DNA repair, and cell cycle progression. However, the functions of many of these PTMs remain uncharacterized. Here, we demonstrate a role for acetylation at lysine 134 on lamin B1 in slowing the G1 to S cell cycle transition by inhibiting resolution of DNA damage by canonical nonhomologous end joining.
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_12:46:58.963.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Murray
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-07 04:46:21	ID requested
⏵ 1	2021-03-04 12:46:59	announced

Dataset with its publication pending

submitter keyword: Lamin B1, lamin, acetylation, DNA repair, TurboID, nonhomologous end joining

Ileana M. Cristea
contact affiliation	Department of Molecular Biology, Princeton University
contact email	icristea@princeton.edu
lab head
Laura Murray
contact affiliation	Princeton University
contact email	lamurray@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD022974

PRIDE project URI

• PRIDE
  1. PXD022974
     1. Label: PRIDE project
     2. Name: Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair