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PXD022970

PXD022970 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePLK1 phosphorylation of Epstein-Barr virus nuclear antigen 2
DescriptionThe Epstein-Barr virus nuclear antigen 2 (EBNA2) initiates and maintains the proliferation of infected B cells. In search of additional cellular strategies, that control EBNA2 function, we have performed a label-free mass spectrometry-based quantification of cellular proteins in EBNA2 immuno-precipitates and found polo-like kinase 1 (PLK1) to be bound to EBNA2. EBNA2/PLK1 complex formation is strongly enforced by EBNA2 S379 phosphorylation catalyzed by the mitotic CYCLIN B/CDK1 complex.
HostingRepositoryPRIDE
AnnounceDate2021-08-22
AnnouncementXMLSubmission_2021-10-14_01:05:02.117.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPiero Giansanti
SpeciesList scientific name: Human herpesvirus 4 strain B95-8; NCBI TaxID: 10377;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-12-07 03:55:21ID requested
12021-08-22 06:01:33announced
22021-10-14 01:05:02announced2021-10-14: Updated publication reference for PubMed record(s): 34605140.
Publication List
Zhang X, Schuhmachers P, Mour, ã, o A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, K, ü, ppers R, Kuster B, Raab M, Strebhardt K, Sattler M, M, ü, nz C, Kempkes B, PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice. EMBO Rep, 22(12):e53007(2021) [pubmed]
Keyword List
submitter keyword: Phosphoproteomics, mass spectrometry, cancer
Contact List
Bernhard Kuster
contact affiliationChair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, D-85354, Freising, Germany Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Gregor-Mendel-Strasse 4, D-85354, Freising, Germany
contact emailkuster@tum.de
lab head
Piero Giansanti
contact affiliationTechnical University of Munich
contact emailpiero.giansanti@tum.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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