PXD022970 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PLK1 phosphorylation of Epstein-Barr virus nuclear antigen 2 |
Description | The Epstein-Barr virus nuclear antigen 2 (EBNA2) initiates and maintains the proliferation of infected B cells. In search of additional cellular strategies, that control EBNA2 function, we have performed a label-free mass spectrometry-based quantification of cellular proteins in EBNA2 immuno-precipitates and found polo-like kinase 1 (PLK1) to be bound to EBNA2. EBNA2/PLK1 complex formation is strongly enforced by EBNA2 S379 phosphorylation catalyzed by the mitotic CYCLIN B/CDK1 complex. |
HostingRepository | PRIDE |
AnnounceDate | 2021-08-22 |
AnnouncementXML | Submission_2021-10-14_01:05:02.117.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Piero Giansanti |
SpeciesList | scientific name: Human herpesvirus 4 strain B95-8; NCBI TaxID: 10377; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-07 03:55:21 | ID requested | |
1 | 2021-08-22 06:01:33 | announced | |
⏵ 2 | 2021-10-14 01:05:02 | announced | 2021-10-14: Updated publication reference for PubMed record(s): 34605140. |
Publication List
Zhang X, Schuhmachers P, Mour, ã, o A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, K, ü, ppers R, Kuster B, Raab M, Strebhardt K, Sattler M, M, ü, nz C, Kempkes B, PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice. EMBO Rep, 22(12):e53007(2021) [pubmed] |
Keyword List
submitter keyword: Phosphoproteomics, mass spectrometry, cancer |
Contact List
Bernhard Kuster |
contact affiliation | Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, D-85354, Freising, Germany Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Gregor-Mendel-Strasse 4, D-85354, Freising, Germany |
contact email | kuster@tum.de |
lab head | |
Piero Giansanti |
contact affiliation | Technical University of Munich |
contact email | piero.giansanti@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD022970
- Label: PRIDE project
- Name: PLK1 phosphorylation of Epstein-Barr virus nuclear antigen 2