PXD022946

PXD022946 is an original dataset announced via ProteomeXchange.

Title	The histone methyltransferase SETD2 couples transcription and splicing by engaging pre-mRNA processing factors through its SHI domain
Description	The domains of SETD2, a known histone methyltransferase were investigated for specific interaction partners and function using a number of biochemical assays and affinity purification mass spectrometry. The C-terminal domain, named SETD2C, was identified to interact with hnRNP-L through a previously uncharacterized domain. These findings demonstrate the crosstalk between the transcription and splicing machinery.
HostingRepository	PRIDE
AnnounceDate	2021-02-01
AnnouncementXML	Submission_2021-04-06_02:52:57.223.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD022946
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michaella Levy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-07 00:30:48	ID requested
1	2021-01-31 22:31:27	announced
⏵ 2	2021-04-06 02:52:58	announced	2021-04-06: Updated publication reference for PubMed record(s): 33664260.

Bhattacharya S, Levy MJ, Zhang N, Li H, Florens L, Washburn MP, Workman JL, The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain. Nat Commun, 12(1):1443(2021) [pubmed]

submitter keyword: chromatin, mediator, complex, hnRNP, domain

Laurence Florens
contact affiliation	Stowers Institute for Medical Research
contact email	laf@stowers.org
lab head
Michaella Levy
contact affiliation	Stowers Institute for Medical Research
contact email	mly@stowers.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022946
     1. Label: PRIDE project
     2. Name: The histone methyltransferase SETD2 couples transcription and splicing by engaging pre-mRNA processing factors through its SHI domain