PXD022926

PXD022926 is an original dataset announced via ProteomeXchange.

Title	Nano-LC-MS/MS proteomics in amniotic fluid from CAKUT patients
Description	The objective of the present work was to identify new renal proteins responsible for Congenital Anomalies of the Kidney and of the Urinary Tract (CAKUT pathophysiology). We conducted a comparative LC-MS/MS-based proteomics analysis of amniotic fluids (AF) collected from non-severe CAKUT (ns-CAKUT; n=19), severe CAKUT (s-CAKUT; n=14), and healthy controls (cont; n=22) fetuses. We identified a total of 224 gestational age independent proteins that were significantly different in abundance when comparing (one-way ANOVA corrected p<0.05) the 3 groups of amniotic fluids 2 by 2. We identified 8 gestational-age independent proteins that were in common when comparing the 3 groups two by two, and that were considered as associated to both CAKUT onset and CAKUT severity.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:28.675.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mylène CAMUS
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-04 07:44:37	ID requested
1	2023-09-26 04:33:23	announced
⏵ 2	2023-11-14 09:05:37	announced	2023-11-14: Updated project metadata.

F, é, dou C, Camus M, Lescat O, Feuillet G, Mueller I, Ross B, Bul, é, on M, Neau E, Alves M, Goudoun, é, che D, Breuil B, Boizard F, Bardou Q, Casemayou A, Tack I, Dreux S, Batut J, Blader P, Burlet-Schiltz O, Decramer S, Wirth B, Klein J, Saulnier-Blache JS, Buffin-Meyer B, Schanstra JP, Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity. J Pathol, 254(5):575-588(2021) [pubmed]

submitter keyword: chronic kidney disease,CAKUT, proteomics, plastin-3, amniotic fluid

Joost-Peter Schanstra
contact affiliation	I2MC Inserm U1048 - Toulouse
contact email	joost-peter.schanstra@inserm.fr
lab head
Mylène CAMUS
contact affiliation	CNRS
contact email	mylene.camus@ipbs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD022926

PRIDE project URI

• PRIDE
  1. PXD022926
     1. Label: PRIDE project
     2. Name: Nano-LC-MS/MS proteomics in amniotic fluid from CAKUT patients