PXD022921

PXD022921 is an original dataset announced via ProteomeXchange.

Title	Control of protein accumulation by the LON2 peroxisomal protease and autophagy
Description	Peroxisomes are membrane-bound eukaryotic organelles that house essential metabolic pathways. Many of these pathways generate damaging reactive oxygen species (ROS) that also function as signaling molecules. In Arabidopsis thaliana, damaged or obsolete peroxisomal proteins can be degraded by the LON2 peroxisomal protease. In addition, peroxisomes can be entirely degraded through a specialized form of autophagy (pexophagy), a process that is amplified when LON2 is dysfunctional. As a first step towards identifying LON2 substrates, we used proteomic analysis to compare proteins that accumulate when LON2 is dysfunctional in the presence and absence of autophagy.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:42:06.172.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD022921
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bonnie Bartel
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-04 03:17:22	ID requested
⏵ 1	2025-05-06 09:42:07	announced

10.6019/PXD022921;

Muhammad D, Clark NM, Tharp NE, Chatt EC, Vierstra RD, Bartel B, Global impacts of peroxisome and pexophagy dysfunction revealed through multi-omics analyses of lon2 and atg2 mutants. Plant J, 120(6):2563-2583(2024) [pubmed]

10.1111/tpj.17129;

submitter keyword: protease, peroxisomes, pexophagy, chaperone

Bonnie Bartel
contact affiliation	Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA
contact email	bartel@rice.edu
lab head
Bonnie Bartel
contact affiliation	Rice University
contact email	bartel@rice.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD022921

PRIDE project URI

• PRIDE
  1. PXD022921
     1. Label: PRIDE project
     2. Name: Control of protein accumulation by the LON2 peroxisomal protease and autophagy