PXD022856

PXD022856 is an original dataset announced via ProteomeXchange.

Title	Complexome profiling of mitochondrial protein complexes to study assembly of complex III and supercomplex stability in patients with defects in UQCRH gene
Description	UQCRH, also called the hinge protein, is a small subunit of Ubiquinol—cytochrome-c reductase (complex III). Here we used a complexome analysis of primary and immortalized fibroblasts from patients with a homozygous 2 exon deletion in the UQCRH gene and analyzed complex III assembly and altered supercomplex composition.
HostingRepository	PRIDE
AnnounceDate	2021-09-20
AnnouncementXML	Submission_2021-09-20_03:16:03.516.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-01 23:11:45	ID requested
⏵ 1	2021-09-20 03:16:03	announced

Dataset with its publication pending

submitter keyword: complexome profiling, oxidative phosphorylation system, supercomplexes, complex III assembly

Robert Taylor
contact affiliation	Highly Specialised Mitochondrial Diagnostic Laboratory, Wellcome Centre for Mitochondrial Research, Newcastle University, UK
contact email	robert.taylor@ncl.ac.uk
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022856
     1. Label: PRIDE project
     2. Name: Complexome profiling of mitochondrial protein complexes to study assembly of complex III and supercomplex stability in patients with defects in UQCRH gene