PXD022798

PXD022798 is an original dataset announced via ProteomeXchange.

Title	Proteomic identification of new diagnostic biomarkers of early-stage cutaneous mycosis fungoides
Description	Primary cutaneous T-cell lymphoma (CTCL) is responsible for two-thirds of cutaneous lymphoma cases. Mycosis fungoides (MF), the most common subtype of CTCL comprises approximately 60% of CTCLs. Due to the similar clinical features of MF and inflammatory diseases such as eczema and psoriasis, early-stage MF can easily be misdiagnosed as chronic inflammatory dermatoses, posing a diagnostic challenge to the dermatologist. Early-stage MF is characterized by a favorable prognosis with long-term survival similar to or slightly lower than that of age-matched healthy people, with a 5-year survival between 88% and 100%. In contrast, advanced-stage MF shows aggressive progression, and the median survival time of patients with lymph node and visceral involvement is only 13 months. Therefore, it is important to achieve early diagnosis to improve prognosis, yet there are few specific biomarkers for the early diagnosis and prognosis of MF. In this study, we described the pathological features of MF during the early and advanced stages through proteomics technology, providing clues for the pathogenesis of MF as well as biomarkers for malignant tumors in the early stage. More importantly, diagnostic biomarkers of early-stage MF were identified by comparing the proteomic characteristics of early-stage MF and inflammatory diseases, with the goal of preventing delayed therapy due to misdiagnosis.
HostingRepository	iProX
AnnounceDate	2020-11-28
AnnouncementXML	Submission_2022-11-21_19:33:25.759.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Leng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-28 04:51:56	ID requested
⏵ 1	2022-11-21 19:33:26	announced

Leng L, Liu Z, Ma J, Zhang S, Wang Y, Lv L, Zhu Y, Gao D, Wang Y, Wang J, Liu Y, Liu J, Proteomic identification of new diagnostic biomarkers of early-stage cutaneous mycosis fungoides. Cancer Commun (Lond), 42(6):558-562(2022) [pubmed]

submitter keyword: Mycosis fungoides, proteomics, diagnostic biomarker

Jie Liu
contact affiliation	Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.
contact email	Liujie04672@pumch.cn
lab head
Ling Leng
contact affiliation	Stem cell and Regenerative Medicine Lab, State Key Laboratory of Complex Severe and Rare Diseases, Department of Medical Science Research Center, Peking Union Medical College Hospital.
contact email	zhenlinger@126.com
dataset submitter

iProX dataset URI