PXD022774

PXD022774 is an original dataset announced via ProteomeXchange.

Title	Proteome-wide identification lncRNA CCAT1 directly binding proteins by RAP-MS
Description	We purify and identify CCAT1 binding proteins by RAP-MS. As a result, we identified out more than 600 CCAT1 binding proteins and more than 60% of them are RNA binding proteins recorded by RBPs database EuRBPDB. Among the identified CCAT1 binding proteins, Vimentin is a crucial protein. Additionally, CCAT1 could positively influence the protein level of Vimentin and enhance migration and invasion ability of cancer cells. Our data indicate that CCAT1 may bind and stabilize Vimentin enhancing the migration and invasion ability of cancer Cell.
HostingRepository	iProX
AnnounceDate	2020-11-26
AnnouncementXML	Submission_2023-10-26_19:12:27.610.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhangfu Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-26 18:24:21	ID requested
1	2020-11-26 18:38:53	announced
⏵ 2	2023-10-26 19:12:28	announced	2023-10-27: Update publication information.

Li Z, Yuan J, Da Q, Yan Z, Qu J, Li D, Liu X, Zhan Q, Liu J, Long non-coding RNA colon cancer-associated transcript 1-Vimentin axis promoting the migration and invasion of HeLa cells. Chin Med J (Engl), 136(19):2351-2361(2023) [pubmed]

submitter keyword: CCAT1, Vimentin, RAP-MS

Jikui Liu
contact affiliation	Peking University Shenzhen Hospital
contact email	Liu8929@126.com
lab head
Zhangfu Li
contact affiliation	Peking University Shenzhen Hospital
contact email	lizhf1990@sina.com
dataset submitter

iProX dataset URI