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PXD022770

PXD022770 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSpore formation in a parasitic cnidarian: proteomic analysis of Ceratonova shasta (Cnidaria: Myxozoa)
DescriptionMyxozoans are widely distributed aquatic obligate endoparasites that were recently recognized as belonging within the phylum Cnidaria. They have complex life cycles with waterborne transmission stages: resistant, infectious spores that are unique to myxozoans. However, little is known about the processes that give rise to these transmission stages. To understand the molecular underpinnings of spore formation, we conducted proteomics on Ceratonova shasta, a highly pathogenic myxozoan that causes severe mortalities in wild and hatchery-reared salmonid fishes. We compared proteomic profiles between developmental stages from inside the fish host, and the mature myxospore, which is released into the water where it drifts passively, ready to infect the next host. We found that C. shasta contains 2123 proteins; representing the first proteomic catalog of a myxozoan myxospore. Analysis of proteins differentially expressed between developing and mature spore stages uncovered processes that are active during spore formation. Our data highlight dynamic changes in the actin cytoskeleton, which provides myxozoan developmental stages with mobility through lamellipodia and filopodia, whereas in the mature myxospore the actin network supports F-actin stabilization that reinforces the transmission stage. These findings provide molecular insight into the myxozoan life cycle stages and, particularly, into the process of sporogenesis.
HostingRepositoryPRIDE
AnnounceDate2021-04-06
AnnouncementXMLSubmission_2021-04-05_23:11:51.659.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD022770
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterTal BioInfo
SpeciesList scientific name: Ceratonova shasta; NCBI TaxID: 60662;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-26 06:19:48ID requested
12021-04-05 23:11:56announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Cnidaria, Myxozoa, parasite, sporogenesis, cytoskeleton, actin
Contact List
Tamar Lotan
contact affiliationMarine Biology Department, The Leon H.Charney School of Marine Sciences, University of Haifa, Israel
contact emaillotant@univ.haifa.ac.il
lab head
Tal BioInfo
contact affiliationUniversity of Haifa
contact emailkaktust.uni@gmail.com
dataset submitter
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Dataset FTP location
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