PXD022765

PXD022765 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identifying a GSK3-TRARG1 signaling axis reveals BCL9L as a novel regulator of GLUT4 trafficking
Description	The trafficking regulator of GLUT4-1 (TRARG1) protein positively regulates insulin-stimulated GLUT4 trafficking. Here we identify post-translational modifications on TRARG1 and identify that GSK3 is the upstream kinase responsible for TRARG1 phosphorylation at Serines 72, 76, and 80. We employ affinity enrichment mass spectrometry to identify protein interactions regulated by TRARG1 phosphorylation.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-11_22:24:11.855.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sean Humphrey
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF-X; Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-26 03:19:01	ID requested
⏵ 1	2022-08-11 22:24:12	announced

Publication List

Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ, Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochem J, 479(11):1237-1256(2022) [pubmed]

Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ, Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochem J, 479(11):1237-1256(2022) [pubmed]

Keyword List

submitter keyword: phosphorylation, TRARG1, BCL9L, GLUT4, trafficking

submitter keyword: phosphorylation, TRARG1, BCL9L, GLUT4, trafficking

Contact List

David E James
contact affiliation	Chair in Metabolic Systems Biology, Charles Perkins Centre, The University of Sydney, Australia
contact email	david.james@sydney.edu.au
lab head
Sean Humphrey
contact affiliation	The University of Sydney
contact email	sean.j.humphrey@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD022765
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD022765

PRIDE project URI

Repository Record List

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